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I型糖尿病血脂及脂蛋白的相关因素：EURODIAB IDDM并发症研究
AIM: To assess the determinants and prevalence of hyperlipidaemia
in Type 1 diabetic patients in the EURODIAB IDDM Complications Study.
METHODS: Standardized questionnaire data were obtained and anthropometric
and biochemical measurements performed on 3159 Type 1 diabetic patients,
randomly selected from 31 diabetes clinics. Plasma lipid levels were
determined centrally, using enzymatic methods RESULTS: Plasma total
cholesterol, high-density lipoprotein cholesterol (HDL-C), and HDL
subfractions were higher in women than in men, while plasma triglycerides
were higher in men (P < 0.001). Total cholesterol, low-density
lipoprotein cholesterol (LDL-C) and HDL-C and HDL-C subfractions were,
as expected, significantly associated with age and HbA1c in both sexes.
Age and HbA1c adjusted values of triglyceride, total cholesterol,
LDL-C, HDL-C and HDL3-C in men and triglyceride and HDL2-C in women
showed significant associations with central obesity, measured as
the waist to hip ratio (WHR). Current smokers had lipid profiles characteristic
of insulin resistance in comparison to nonsmokers. Significant positive
associations were observed between hypertension and plasma triglycerides,
total cholesterol and LDL-C in men and women. In men, degree of physical
activity was negatively associated with triglyceride and positively
related to HDL-C and HDL3-C. The prevalence of LDL-hypercholesterolaemia
(LDL-C > 3.35 mmol/L) was 45% in men and in women, while plasma
triglyceride levels > 1.7 mmol/L were observed in 12% of men and
8% of women. CONCLUSION: The results of this study indicate that lipid
levels in Type 1 diabetic patients are strongly influenced by smoking
habit and central obesity in a way that is characteristic of the insulin
resistance syndrome.
【引自Diabet Med 2001 Oct;18(10):786-96】 |
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