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生长停止的女孩糖尿病控制情况恶化：与体重指数的关系
AIM : Diabetic patients, particularly girls, often experience poor
metabolic control during puberty and adolescence. The aim of this
study was to investigate metabolic control during adolescence, especially
in relation to pubertal stages, growth, insulin treatment and body
mass index (BMI). METHODS : We studied the records of 38 (consecutive)
girls with prepubertal onset of Type 1 diabetes mellitus. Data from
the age of 10 to 18-20 years were obtained with regard to glycaemic
control, growth, age at menarche, final height and BMI, and analysed
in relation to both chronological age and age at menarche. RESULTS
: HbA1c was lowest 3 years before menarche; mean (+/- sd) 7.6 (+/-
1.2). After the pubertal growth spurt, there was a marked impairment
of metabolic control, the highest level of HbA1c occurring 3 years
after menarche. Mean age at menarche was 13.3 (+/- 1.1) years and
mean linear growth after menarche only 4.7 cm, giving a final height
of 164.9 (+/- 5.3) cm which is 2.7 cm below the Swedish mean. During
adolescence the degree of correlation between BMI and HbA1c continuously
increased, pointing out the effect of body fat on metabolic control
in this age group. The level of HbA1c at 10 years of age could not
predict the metabolic control after cessation of puberty, but prepubertal
BMI appears to be a risk factor for both obesity and poor glycaemic
control in late adolescence. CONCLUSIONS : The highest HbA1c was found
after cessation of growth. Prepubertal BMI is a possible predictor
of metabolic control in adolescent diabetic girls. Diabet. Med. 18,
811-815 (2001)
【引自Diabet Med 2001 Oct;18(10):811-5】 |
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