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维生素D受体基因变异体与II型糖尿病和冠心病的患病情况有关
AIMS: Vitamin D can influence lipolysis and insulin secretion. A common
genetic polymorphism of the vitamin D receptor, which has been found
to be associated with bone mineral density, has also been reported
to be associated with insulin-dependent diabetes mellitus. To test
the influence of the vitamin D receptor polymorphism on the prevalence
of Type 2 diabetes mellitus and coronary artery disease we studied
a population of high-risk patients, who were referred to our clinic
for diagnostic coronary angiography. METHODS: A total of 293 patients
considered at high risk for coronary artery disease because of angina
pectoris and known hypercholesterolaemia underwent diagnostic coronary
angiography. The BsmI vitamin D receptor polymorphism was analysed
by polymerase chain reaction. RESULTS: Prevalence of Type 2 diabetes
mellitus and coronary artery disease was gradually dependent on the
number of B alleles (BB 28%, Bb 13%, bb 8% for Type 2 diabetes mellitus,
P = 0.002; BB 88% Bb 72%, bb 66% coronary artery disease, P = 0.01).
Patients with the BB genotype had an odds ratio of 3.64 (95% confidence
interval 1.53-8.55, P = 0.002) to have Type 2 diabetes mellitus compared
with patients with the bb genotype. CONCLUSIONS: The genotype of the
vitamin D receptor polymorphism determines the prevalence of Type
2 diabetes mellitus and coronary artery disease in a high-risk cohort
population.
【引自Diabet Med 2001 Oct;18(10):842-5】 |
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