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透析患者亲戚的亚临床神经病变的筛查
Despite the availability of improved medical therapy to slow the progression
of nephropathy, a worldwide epidemic of end-stage renal disease (ESRD)
exists. Many patients are not diagnosed until the late stages of disease,
as early kidney disease may be asymptomatic. Ideally all adults would
be routinely screened for evidence of early kidney disease and associated
risk factors such as hypertension and diabetes mellitus. Unfortunately
this would be a massive and expensive undertaking. A more practical,
cost-effective solution might be to direct screening at those individuals
who are known to be at high risk for the development of nephropathy.
The familial clustering of ESRD has been reported for many types of
renal disease. We propose that the routine screening of first- and
second-degree relatives of ESRD patients for nephropathy might be
an efficient way to detect subclinical renal disease. Early detection
and intensive treatment of renal disease may help to curb the current
epidemic of ESRD.
【引自Semin Dial 2001 Sep-Oct;14(5):311-3】 |
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