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炭疽杆菌毒素
Bacillus anthracis, a gram positive bacterium, is the causative agent
of anthrax. This organism is capsulogen and toxinogenic. It secretes
two toxins which are composed of three proteins: the protective antigen
(PA), the lethal factor (LF) and the edema factor (EF). The lethal
toxin (PA+LF) provokes a subit death in animals, the edema toxin (PA+EF)
induces edema. The edema and the lethal factors are internalised into
the eukaryotic target cells via the protective antigen. EF and LF
exert a calmoduline dependent adenylate cyclase and a metalloprotease
activity respectively. Progress in the structure-function relationship
of these three proteins, their regulation mechanisms and their roles
in pathogenesis and immunoprotection will be exposed.
【引自Toxicon 2001 Nov;39(11):1747-55】 |
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