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胰岛移植对糖尿病的治疗作用
Pancreatic islet transplantation in the treatment of diabetes mellitus. This chapter reviews current developments and
future directions in clinical islet transplantation. With the recent introduction
of glucocorticoid-free immunosuppressive therapies and improved methods
for islet isolation, the success of the procedure has increased substantially.
Challenges ahead include progress with international multicentre trials,
development of single donor protocols, progress in clinical tolerance
based therapies to lower overall risk of immunosuppression, and ultimately
finding an alternative source to provide effective therapy for more patients
with diabetes. Recent advances in stem cell biology and xenotransplantation
may soon provide this opportunity. Copyright 2001 Harcourt Publishers
Ltd. |