独立人群中背景连锁不平衡的基因组广泛分布
[引自Hum Mol Genet 2001 Mar 1;10(5):545-551]
Recent interest in using association studies to investigate complex
traits has focused attention on understanding linkage disequilibrium
(LD) in the human genome. We examined the genome-wide distribution and
magnitude of such background LD (BLD) using 1036 densely spaced microsatellites,
in a sample from the demographically well characterized population of
the Central Valley of Costa Rica. High levels of BLD were found between
linked markers several centiMorgans apart, and although BLD was significantly
related to genetic distance between markers it was not spread uniformly
throughout the genome. Understanding the forces governing the distribution
of BLD in the genome will require similar investigations using a standard
set of markers in other populations.
