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肺炎治疗最新观念
Management of Pneumonia: Are You Really Up to
Date?
Disclosures
Henry Masur, MD
Introduction
At the 32nd Critical Care Congress in San Antonio, Texas,
management of pneumonia was an important topic of discussion.
A panel of experts discussed current concepts of pneumonia
management, focusing on therapy and prevention.
Prevention
of Ventilator-Associated Pneumonia
Do
Anaerobes Really Cause Pneumonia?
Continuous
Dosing of Antibiotics for Pneumonia
Use
of Combination Therapy in Pneumonia
References
1. Kollef MH. Infection: pneumonia. Cutting edge strategies
for the prevention of ventilator-associated pneumonia.
Program and abstracts of the 32nd Critical Care Congress;
January 28-February 2, 2003; San Antonio, Texas.
2. Shorr AF, O'Malley PG. Continuous subglottic suctioning
for the prevention of ventilator-associated pneumonia:
Potential economic implications. Chest. 2001;119:228-235.
3. Prince AS. Biofilms, antimicrobial resistance, and
airway infection. N Engl J Med. 2002;347:1110-1111.
4. Perl TM, Cullen JJ, Wenzel RP, et al. Intranasal
mupirocin to prevent postoperative Staphylococcus aureus
infections. N Engl J Med. 2002;346:1871-1877.
5. Giles FJ, Redman R, Yazji S, Bellm L. Iseganan HCl:
a novel antimicrobial agent. Expert Opin Investig Drugs.
2002;11:1161-1170.
6. Marik P. Infection: pneumonia. Is it necessary to
provide coverage against obligate anaerobes? Program
and abstracts of the 32nd Critical Care Congress; January
28-February 2, 2003; San Antonio, Texas.
7. Bartlett JG. Anaerobic bacterial pneumonitis. Am
Rev Respir Dis. 1979;119:19-23.
8. Bartlett JG. Anaerobic bacterial infections of the
lung and pleural space. Clin Infect Dis. 1993;16(suppl
4):S248-S255.
9. Marik PE, Careau P. The role of anaerobes in patients
with ventilator-associated pneumonia and aspiration
pneumonia: a prospective study. Chest. 1999;115:178-183.
10. Nicolau DP. Infection: pneumonia. Continuous versus
intermittent dosing of beta-lactam antibiotics for pneumonia.
Program and abstracts of the 32nd Critical Care Congress;
January 28-February 2, 2003; San Antonio, Texas.
11. Kuti JL, Nightingale CH, Quintiliani R, Nicolau
DP. Pharmacodynamic profiling of continuously infused
piperacillin/tazobactam against Pseudomonas aeruginosa
using Monte Carlo analysis. Diagn Microbiol Infect Dis.
2002;44:51-57.
12. Wunderink RG. Infection: pneumonia. Single versus
double agent coverage. Program and abstracts of the
32nd Critical Care Congress; January 28-February 2,
2003; San Antonio, Texas.
13. Waterer GW, Somes GW, Wunderink RG. Monotherapy
may be suboptimal for severe bacteremic pneumococcal
pneumonia. Arch Intern Med. 2001;161:1837-1842.
14. Mitchell LS, Tuomanen EI. Molecular analysis of
antibiotic tolerance in pneumococci. Int J Med Microbiol.
2002;292:75-79.
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