Pediatric Issues 　　The third speaker in this session, Adrienne Randolph, MD,[11] of Children's Hospital, Boston, Massachusetts, presented data from her recent JAMA paper assessing the effect of weaning protocols on respiratory outcomes in children.[12] This was a study of 182 pediatric patients in the ICUs of 10 North American hospitals carried out between November 1999 and April 2001. Patients were randomly assigned to a mode of ventilation that was either pressure- or volume-supported. The duration of weaning and rate of failure of extubation were measured as main outcome measures. The study team found no difference between the 2 approaches (pressure vs volume), but did note that in contrast to adults, children are typically weaned from the ventilator much faster (median wean duration was 2 days). They concluded that in children, weaning protocols did not affect the rate or likelihood of success of any given wean, largely because this is not a prolonged process in most cases. 版权所有：好医生网站