 |
Parenchymal Lung Injury Effects on Alveolar Structure
and Function
Parenchymal lung injury refers to any disease process
that injures the alveolar regions of the lung. Examples
include exudative pneumonia, interstitial pneumonia,
aspiration injury, and the acute respiratory distress
syndrome (ARDS). A characteristic feature of all these
processes is alveolar flooding and collapse from combinations
of inflammatory exudates, alveolar/interstitial edema,
and loss of surfactant function.
One of the most striking physiologic effects of alveolar
flooding and collapse is the development of low ventilation/perfusion
(V/Q) lung units and shunts, which can produce profound
hypoxemia. This same process also produces a much "stiffer"
lung with consequently lower compliance values and "flattening"
of the pressure volume relationship.
|
|
|
|
| 版权所有：好医生网站 |
|
