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西地那非在选择性五羟色胺再摄取抑制剂
所致的女性性功能障碍中的治疗作用
OBJECTIVE: To review the literature describing female orgasmic disorder
and impaired sexual desire disorder by selective serotonin reuptake
inhibitors (SSRIs) and their treatment, including the use of sildenafil.
STUDY DESIGN: Literature reviews of all available published articles
on this topic from 1989 to 1996 were done. This paper also includes
a sample case of a 38-year old woman who suffers from fluoxetine-induced
arousal and orgasmic disturbance. RESULTS: Treatment approaches include
the use of "antidotes," such as cyproheptadine, yohimbine,
amantadine, granisetron and ginkgo biloba. This article also reports
a case of successful female use of sildenafil, which was released
by the Food and Drug Administration in March 1998 for erectile dysfunction
in men. CONCLUSION: Sildenafil is beneficial in reversing female sexual
dysfunction induced by SSRIs. This paper also discusses sildenafil's
action in the background of nitric oxide and cyclic guaninosine monophosphate
in penile/clitoral erection.
【引自J Reprod Med 1999 Jun;44(6):535-42】 |
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