焦虑与阿尔茨海默病

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This study investigated symptoms of anxiety in two samples of clinic outpatients
diagnosed with Alzheimer's disease (AD). Clinician and caregiver reports were
obtained using standardized measures to characterize a broad array of anxiety
symptoms. Anxiety symptoms were reported for a substantial proportion of
subjects, regardless of whether clinician or caregiver ratings were used.
Anxious or worried appearance was most common (68% to 71%), followed by
fearfulness, tension, restlessness, and fidgeting (37% to 57%). Sleep
disturbance and various somatic symptoms were less common (8% to 34%). Although
anxiety symptoms were prevalent, only 5% to 6% of subjects met Diagnostic and
Statistical Manual of Mental Disorders criteria for the diagnosis of generalized
anxiety disorder. In both samples, anxiety symptoms were associated with
depression, behavioral disturbances, and increased cognitive impairment. Study
findings support a high occurrence of anxiety in patients with dementia, and
treatments for anxiety might therefore be helpful in reducing the psychiatric
burden of AD.
[引自J Geriatr Psychiatry Neurol 2001 Spring;14(1):52-8]